How do you know when to quit and when to keep pushing forward? How do you discern when closed doors are supposed to be closed and when you should pick the lock? What do you do when the doors you can't go through are open, beckoning you to come through?
It's difficult. It always is. But it is especially disconcerting when it seems to make no sense which doors are nailed shut and which remain open despite your best efforts to close them.
And then there is the persistent thorn in the side. You know the one that runs so deep it becomes a physical ache, and you reach for the Motrin even though you know that's not the kind of medicine that will heal this thing. Prayer doesn't seem to help. Nor do tears. Nothing helps, not really.
Not even when you get whacked over the head with a 2x4:
7 So to keep me from becoming conceited because of the surpassing greatness of the revelations,  a thorn was given me in the flesh, a messenger of Satan to harass me, to keep me from becoming conceited. 8 Three times I pleaded with the Lord about this, that it should leave me. 9 But he said to me, “My grace is sufficient for you, for my power is made perfect in weakness.” Therefore I will boast all the more gladly of my weaknesses, so that the power of Christ may rest upon me. 10 For the sake of Christ, then, I am content with weaknesses, insults, hardships, persecutions, and calamities. For when I am weak, then I am strong. ESV